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A new study examines the occurrence of interval colorectal cancer despite regular colonoscopy and highlights the importance of close follow-up for patients who have a history of advanced adenomas, which are precancerous polyps. Researchers studied the rate of interval colorectal cancer in patients participating in the Polyp Prevention Trial Continued Follow-up Study and found that nine cases of colorectal cancer were diagnosed over 7,626 person-years of observation for an incidence rate of 1.2 per 1,000 person-years of observation. Of patients in whom colorectal cancer developed, 78 percent had a history of advanced adenoma. The majority of the cancers detected were early stage (78 percent were stage I or II) and therefore highly curable. The study appears in the January issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy.
Colonoscopy is recommended as the primary screening method for colorectal cancer and is the final common pathway for all other recommended screening tests. It is considered the "gold standard" for colorectal cancer screening because of the ability to diagnose and remove polyps (growths) before they become cancer. A recent study by leading cancer groups reported that from 1975 to 2000, colorectal cancer incidence rates dropped 22 percent and death rates dropped 26 percent. The report stated that "screening appears to have had a considerable impact on reducing CRC incidence and mortality."
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